Research Postdoctoral Fellow, The Solomon H. Snyder Department of Neuroscience


Research Interests

I’m interested in the roles of oligodendrocyte precursor cells (OPCs, aka NG2 cells) in maintaining normal brain homeostasis and during pathological conditions.

Education

B.S.    National Chiao Tung University, Taiwan

M.S.    National Taiwan University, Taiwan

Ph.D.    University of Massachusetts Medical School at Worcester

 

Selected Publications

Lu, T.-Y., MacDonald, J.M., Neukomm, L.J., Sheehan, A.E., Bradshaw, R., Logan, M.A., and Freeman, M.R. (2017). Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling. Nat. Commun. 8, 14355.

Srinivasan, R.*, Lu, T.-Y.*, Chai, H.*, Xu, J., Huang, B.S., Golshani, P., Coppola, G., and Khakh, B.S. (2016). New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron 92, 1181–1195. (*: Equal contributions)

Lu, T.-Y., Doherty, J., and Freeman, M.R. (2014). DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris. Proc. Natl. Acad. Sci. U. S. A. 111, 12544–12549.

Doherty, J., Sheehan, A.E., Bradshaw, R., Fox, A.N., Lu, T.-Y., and Freeman, M.R. (2014). PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury. PLoS Biol. 12, e1001985.

Huang, C.-Y., Lu, T.-Y., Bair, C.-H., Chang, Y.-S., Jwo, J.-K., and Chang, W. (2008). A Novel Cellular Protein, VPEF, Facilitates Vaccinia Virus Penetration into HeLa Cells through Fluid Phase Endocytosis. J. Virol. 82, 7988–7999.

Tsai, Y.-H., Kuang, W.-F., Lu, T.-Y., Kao, J.-H., Lai, M.-Y., Liu, C.-J., Chen, P.-J., and Hwang, L.-H. (2008). The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism. J. Hepatol. 49, 899–907.

 

CONTACT INFORMATION

Department of Neuroscience

Johns Hopkins University School of Medicine

725 N. Wolfe St., WBSB 1001

Baltimore, MD 21205

Phone: (410) 955-6949

Fax: (410) 955-6942