{"id":1715,"date":"2010-11-18T00:00:58","date_gmt":"2010-11-18T00:00:58","guid":{"rendered":"http:\/\/bergleslab.com\/wordpress\/?p=1715"},"modified":"2017-10-18T19:37:39","modified_gmt":"2017-10-18T19:37:39","slug":"kang-2010","status":"publish","type":"post","link":"http:\/\/bergleslab.com\/index.php\/2010\/11\/18\/kang-2010\/","title":{"rendered":"NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration."},"content":{"rendered":"
Neuron.<\/a> 2010 Nov 18;68(4):668-81. doi: 10.1016\/j.neuron.2010.09.009.<\/div>\n

NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.<\/h4>\n
Kang SH<\/a>, Fukaya M<\/a>, Yang JK<\/a>, Rothstein JD<\/a>, Bergles DE<\/a>.<\/div>\n

<\/h3>\n
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Abstract<\/h4>\n
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The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+ cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in response to injury and demyelination. Although it has been reported that NG2+ cells are multipotent, their fate in health and disease remains controversial. Here, we generated PDGF\u03b1R-CreER transgenic mice and followed their fate in vivo in the developing and adult CNS. These studies revealed that NG2+ cells in the postnatal CNS generate myelinating oligodendrocytes, but not astrocytes or neurons. In regions of neurodegeneration in the spinal cord of ALS mice, NG2+ cells exhibited enhanced proliferation and accelerated differentiation into oligodendrocytes but remained committed to the oligodendrocyte lineage. These results indicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors.<\/p>\n<\/div>\n

PDF<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+ cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in response to injury and demyelination. Although it has been reported that NG2+ cells are multipotent, their fate in health and disease remains controversial. Here, we generated PDGF\u03b1R-CreER transgenic mice and followed their fate in vivo in the developing and adult CNS. These studies revealed that NG2+ cells in the postnatal CNS generate myelinating oligodendrocytes, but not astrocytes or neurons. In regions of neurodegeneration in the spinal cord of ALS mice, NG2+ cells exhibited enhanced proliferation and accelerated differentiation into oligodendrocytes but remained committed to the oligodendrocyte lineage. These results indicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors.<\/p>\n","protected":false},"author":1,"featured_media":1930,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78,33],"tags":[95,48,74],"class_list":["post-1715","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-original-research","category-publications","tag-adult-neurogenesis","tag-oligodendrocyte-precursor-cells","tag-oligodendrogenesis"],"_links":{"self":[{"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/posts\/1715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/comments?post=1715"}],"version-history":[{"count":3,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/posts\/1715\/revisions"}],"predecessor-version":[{"id":2112,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/posts\/1715\/revisions\/2112"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/media\/1930"}],"wp:attachment":[{"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/media?parent=1715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/categories?post=1715"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/bergleslab.com\/index.php\/wp-json\/wp\/v2\/tags?post=1715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}