Clinical and Research Postdoctoral Fellow, Division of Neuroimmunology, Department of Neurology and The Solomon H. Snyder Department of Neuroscience
Research Interests
Multiple sclerosis pathology; Oligodendrocyte remyelination and nervous system repair
Education
B.S. University of Pennsylvania
M.D., Ph.D. University of Pennsylvania
Selected Publications
Hughes, E.G.*, Orthmann-Murphy, J.L.*, Langseth, A.J., and Bergles, D.E. (2018). Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex. Nat. Neurosci. 21, 696–706. (*: Co-first authors)
Orthmann-Murphy, J.L., and Calabresi, P.A. (2017). Therapeutic Application of Monoclonal Antibodies in Multiple Sclerosis. Clin. Pharmacol. Ther. 101, 52–64.
Orthmann-Murphy, J.L., Salsano, E., Abrams, C.K., Bizzi, A., Uziel, G., Freidin, M.M., Lamantea, E., Zeviani, M., Scherer, S.S., and Pareyson, D. (2009). Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations. Brain 132, 426–438.
Orthmann-Murphy, J.L., Enriquez, A.D., Abrams, C.K., and Scherer, S.S. (2007). Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease. Mol. Cell. Neurosci. 34, 629–641.
Orthmann-Murphy, J.L., Freidin, M., Fischer, E., Scherer, S.S., and Abrams, C.K. (2007). Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins. J. Neurosci. 27, 13949–13957.
CONTACT INFORMATION
Department of Neuroscience
Johns Hopkins University School of Medicine
725 N. Wolfe St., WBSB 1001
Baltimore, MD 21205
Phone: (410) 955-6949
Fax: (410) 955-6942
