Postdoctoral fellow, The Solomon H. Snyder Department of Neuroscience

Research Interests

I’m a postdoctoral fellow in the Solomon H. Snyder Department of Neuroscience and the Center for Hearing and Balance at Johns Hopkins School of Medicine. My research centers on hyperexcitability in common CNS disorders and combines genetic manipulation with cellular and network imaging of neurons, glia, and neurotransmitters to understand basic mechanisms of disease. This work has recently focused on changes in sound processing following hearing loss and the rise of coordinated spontaneous activity that may underlie secondary disorders such as hyperacusis and tinnitus. More broadly, this work may inform other disorders of sound perception, including increased sensitivity to sound in developmental disorders such as autism, and the transient aversion to sound (allodynia) during migraine and following head injuries.

Education

B.S. in Psychology, Boise State University

Ph.D. in Neuroscience, University of Utah

Selected Publications

  1. Kellner V, Parker PD, Mi X, Yu G, Saher G, Bergles DE. Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain. bioRxiv. doi: https://doi.org/10.1101/2024.04.15.589519
  2. Ling JP, Bygrave AM, Santiago CP, et al. Cell-specific regulation of gene expression using splicing-dependent frameshifting. Nat Commun. 2022; 13(1):5773
  3. Parker PD, Suryavanshi P, Melone M, Reinhart KR, Sawant-Pokam PM, Kaufmann D, Theriot JJ, Pugliese A, Conti F, Shuttleworth CW, Pietrobon D, Brennan KC. Non-canonical glutamate signaling in a genetic model of migraine with aura. Neuron. 2021; 109:1-18.
  4. Bogdanov V, Middleton N, Theriot J, Parker PD, Abdullah O, Ju YS, Hartings J, Brennan KC. Susceptibility of primary sensory cortex to spreading depolarizations. Journal of Neuroscience. 2016; 36(17):4733-43.
  5. Bakken TE, et al. A comprehensive transcriptional map of primate brain development. Nature. 2016; 535(7612):367-75.
  6. Miller JA, et al, Transcriptional landscape of the prenatal human brain. Nature. 2014; 508(7495):199-206.
  7. Hawrylycz MJ, et al, An Anatomically Comprehensive Atlas of the Adult Human Brain Transcriptome. Nature. 2012; 489(7416): 391-399.

Contact information

pparke20@jhmi.edu