PhD Student, The Solomon H. Snyder Department of Neuroscience
Research Interests
Norepinephrine-mediated intracellular signaling in astrocytes and its role in transcriptional regulation and astrocyte physiology, interaction between astrocytes and other cell types in the CNS
Education
B.A. Washington University in St. Louis
Selected Publications
Parhizkar, S., Chen, W., Bao, X., Gent, G., Rensing, N., Tycksen, E., Franke, E., Manis, M., Bosch, M. E., Lee, C., Serrano, J. R., Landsness, E., Wong, M., & Holtzman, D. M. (2024). Lemborexant, a Dual Orexin Receptor Antagonist, ameliorates Tau‐mediated Sleep Loss and Neurodegeneration. Alzheimer’s & Dementia, 20(S1), e089253. https://doi.org/10.1002/alz.089253
Zhang, X., Landsness, E. C., Miao, H., Chen, W., Tang, M. J., Brier, L. M., Culver, J. P., Lee, J.-M., & Anastasio, M. A. (2024). Attention-based CNN-BiLSTM for sleep state classification of spatiotemporal wide-field calcium imaging data. Journal of Neuroscience Methods, 411, 110250. https://doi.org/10.1016/j.jneumeth.2024.110250
Parhizkar, S., Gent, G., Chen, Y., Rensing, N., Gratuze, M., Strout, G., Sviben, S., Tycksen, E., Zhang, Q., Gilmore, P. E., Sprung, R., Malone, J., Chen, W., Remolina Serrano, J., Bao, X., Lee, C., Wang, C., Landsness, E., Fitzpatrick, J., … Holtzman, D. M. (2023). Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2 -dependent manner in mice. Science Translational Medicine, 15(693), eade6285. https://doi.org/10.1126/scitranslmed.ade6285
Zhang, X., Landsness, E. C., Chen, W., Miao, H., Tang, M., Brier, L. M., Culver, J. P., Lee, J.-M., & Anastasio, M. A. (2022). Automated sleep state classification of wide-field calcium imaging data via multiplex visibility graphs and deep learning. Journal of Neuroscience Methods, 366, 109421. https://doi.org/10.1016/j.jneumeth.2021.109421
Contact information
Department of Neuroscience
Johns Hopkins University School of Medicine
725 N. Wolfe St., WBSB 1001
Baltimore, MD 21205
Phone: (410) 955-6949
Fax: (410) 955-6942
