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Kim, J., Hughes, E.G., Shetty, A.S., Arlotta, P., Goff, L.A., Bergles, D.E., and Brown, S.P. (2017). Changes in the Excitability of Neocortical Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis Are Not Specific to Corticospinal Neurons and Are Modulated by Advancing Disease. J. Neurosci. 37, 9037–9053.

Assinck, P., Duncan, G.J., Plemel, J.R., Lee, M.J., Stratton, J.A., Manesh, S.B., Liu, J., Ramer, L.M., Kang, S.H., Bergles, D.E., et al. (2017). Myelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury. J. Neurosci. 37, 8635–8654.

Langseth, A.J., Kim, J., Ugolino, J.E., Shah, Y., Hwang, H.-Y., Wang, J., Bergles, D.E., and Brown, S.P. (2017). Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci. Rep. 7, 5685.

Wang, Q., Yue, W.W.S., Jiang, Z., Xue, T., Kang, S.H., Bergles, D.E., Mikoshiba, K., Offermanns, S., and Yau, K.-W. (2017). Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle. Curr. Biol. 27, 1791–1800.e5.

Li, A., Liang, W., Guan, H., Gau, Y.-T.A., Bergles, D.E., and Li, X. (2017). Focus scanning with feedback-control for fiber-optic nonlinear endomicroscopy. Biomed. Opt. Express 8, 2519.

Agarwal, A., Wu, P.-H., Hughes, E.G., Fukaya, M., Tischfield, M.A., Langseth, A.J., Wirtz, D., and Bergles, D.E. (2017). Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93, 587–605.e7.

Biesecker, K.R., Srienc, A.I., Shimoda, A.M., Agarwal, A., Bergles, D.E., Kofuji, P., and Newman, E.A. (2016). Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina. J. Neurosci. 36, 9435–9445.

Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J.J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., et al. (2016). Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks. Elife 5.

Zhang-Hooks, Y., Agarwal, A., Mishina, M., and Bergles, D.E. (2016). NMDA Receptors Enhance Spontaneous Activity and Promote Neuronal Survival in the Developing Cochlea. Neuron 89, 337–350.

Kim, Y.S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L., He, S., LaVinka, P.C., et al. (2016). Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron 91, 1085–1096.

Larson, V.A., Zhang, Y., and Bergles, D.E. (2016). Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles. Brain Res. 1638, 138–160.

Ma, Z., Stork, T., Bergles, D.E., and Freeman, M.R. (2016). Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour. Nature 539, 428–432.

Jin, J., Peng, Q., Hou, Z., Jiang, M., Wang, X., Langseth, A.J., Tao, M., Barker, P.B., Mori, S., Bergles, D.E., et al. (2015). Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington’s disease. Hum. Mol. Genet. 24, 2508–2527.

Wang, H.C., Lin, C.-C., Cheung, R., Zhang-Hooks, Y., Agarwal, A., Ellis-Davies, G., Rock, J., and Bergles, D.E. (2015). Spontaneous Activity of Cochlear Hair Cells Triggered by Fluid Secretion Mechanism in Adjacent Support Cells. Cell 163, 1348–1359.

Wang, H.C., and Bergles, D.E. (2015). Spontaneous activity in the developing auditory system. Cell Tissue Res. 361, 65–75.

Rosa, J.M., Bos, R., Sack, G.S., Fortuny, C., Agarwal, A., Bergles, D.E., Flannery, J.G., and Feller, M.B. (2015). Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. Elife 4.

Placone, A.L., McGuiggan, P.M., Bergles, D.E., Guerrero-Cazares, H., Quiñones-Hinojosa, A., and Searson, P.C. (2015). Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix. Biomaterials 42, 134–143.

Bergles, D.E., and Richardson, W.D. (2015). Oligodendrocyte Development and Plasticity. Cold Spring Harb. Perspect. Biol. 8, a020453.

Nimmerjahn, A., and Bergles, D.E. (2015). Large-scale recording of astrocyte activity. Curr. Opin. Neurobiol. 32, 95–106.

Otsu, Y., Couchman, K., Lyons, D.G., Collot, M., Agarwal, A., Mallet, J.-M., Pfrieger, F.W., Bergles, D.E., and Charpak, S. (2015). Calcium dynamics in astrocyte processes during neurovascular coupling. Nat. Neurosci. 18, 210–218.

Mellado Lagarde, M.M., Wan, G., Zhang, L., Gigliello, A.R., McInnis, J.J., Zhang, Y., Bergles, D., Zuo, J., and Corfas, G. (2014). Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse. Proc. Natl. Acad. Sci. 111, 16919–16924.

Paukert, M., Agarwal, A., Cha, J., Doze, V.A., Kang, J.U., and Bergles, D.E. (2014). Norepinephrine controls astroglial responsiveness to local circuit activity. Neuron 82, 1263–1270.

Agarwal, A., and Bergles, D.E. (2014). Astrocyte morphology is controlled by neuron-derived FGF. Neuron 83, 255–257.

Issa, J.B., Haeffele, B.D., Agarwal, A., Bergles, D.E., Young, E.D., and Yue, D.T. (2014). Multiscale optical Ca2+ imaging of tonal organization in mouse auditory cortex. Neuron 83, 944–959.

Baxi, E.G., Schott, J.T., Fairchild, A.N., Kirby, L.A., Karani, R., Uapinyoying, P., Pardo-Villamizar, C., Rothstein, J.R., Bergles, D.E., and Calabresi, P.A. (2014). A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation. Glia 62, 1513–1529.

Filous, A.R., Tran, A., Howell, C.J., Busch, S.A., Evans, T.A., Stallcup, W.B., Kang, S.H., Bergles, D.E., Lee, S., Levine, J.M., et al. (2014). Entrapment via synaptic-like connections between NG2 proteoglycan+ cells and dystrophic axons in the lesion plays a role in regeneration failure after spinal cord injury. J. Neurosci. 34, 16369–16384.

Hughes, E.G., and Bergles, D.E. (2014). Hidden progenitors replace microglia in the adult brain. Neuron 82, 253–255.

Hughes, E.G., Kang, S.H., Fukaya, M., and Bergles, D.E. (2013). Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat. Neurosci. 16, 668–676.

Wong, A.D., Ye, M., Levy, A.F., Rothstein, J.D., Bergles, D.E., and Searson, P.C. (2013). The blood-brain barrier: an engineering perspective. Front. Neuroeng. 6, 7.

Kang, S.H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D.W., Ostrow, L.W., Rothstein, J.D., and Bergles, D.E. (2013). Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat. Neurosci. 16, 571–579.

Dickendesher, T.L., Baldwin, K.T., Mironova, Y.A., Koriyama, Y., Raiker, S.J., Askew, K.L., Wood, A., Geoffroy, C.G., Zheng, B., Liepmann, C.D., et al. (2012). NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat. Neurosci. 15, 703–712.

Holmseth, S., Dehnes, Y., Huang, Y.H., Follin-Arbelet, V. V, Grutle, N.J., Mylonakou, M.N., Plachez, C., Zhou, Y., Furness, D.N., Bergles, D.E., et al. (2012). The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS. J. Neurosci. 32, 6000–6013.

Paukert, M., and Bergles, D.E. (2012). Reduction of motion artifacts during in vivo two-photon imaging of brain through heartbeat triggered scanning. J. Physiol. 590, 2955–2963.

Benediktsson, A.M., Marrs, G.S., Tu, J.C., Worley, P.F., Rothstein, J.D., Bergles, D.E., and Dailey, M.E. (2012). Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia 60, 175–188.

Holmseth, S., Zhou, Y., Follin-Arbelet, V. V, Lehre, K.P., Bergles, D.E., and Danbolt, N.C. (2012). Specificity controls for immunocytochemistry: the antigen preadsorption test can lead to inaccurate assessment of antibody specificity. J. Histochem. Cytochem. 60, 174–187.

De Biase, L.M., Kang, S.H., Baxi, E.G., Fukaya, M., Pucak, M.L., Mishina, M., Calabresi, P.A., and Bergles, D.E. (2011). NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J. Neurosci. 31, 12650–12662.

De Biase, L.M., and Bergles, D.E. (2011). Same players, different game: AMPA receptor regulation in oligodendrocyte progenitors. Nat. Neurosci. 14, 1358–1360.

Boersma, M.C.H., Dresselhaus, E.C., De Biase, L.M., Mihalas, A.B., Bergles, D.E., and Meffert, M.K. (2011). A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis. J. Neurosci. 31, 5414–5425.

Tritsch, N.X., and Bergles, D.E. (2010). Developmental regulation of spontaneous activity in the Mammalian cochlea. J. Neurosci. 30, 1539–1550.

Kang, S.H., Fukaya, M., Yang, J.K., Rothstein, J.D., and Bergles, D.E. (2010). NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 68, 668–681.

Tritsch, N.X., Rodríguez-Contreras, A., Crins, T.T.H., Wang, H.C., Borst, J.G.G., and Bergles, D.E. (2010). Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset. Nat. Neurosci. 13, 1050–1052.

Paukert, M., Huang, Y.H., Tanaka, K., Rothstein, J.D., and Bergles, D.E. (2010). Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. J. Neurosci. 30, 7290–7299.

Tritsch, N.X., Zhang, Y.-X., Ellis-Davies, G., and Bergles, D.E. (2010). ATP-induced morphological changes in supporting cells of the developing cochlea. Purinergic Signal. 6, 155–166.

Bergles, D.E., Jabs, R., and Steinhäuser, C. (2010). Neuron-glia synapses in the brain. Brain Res. Rev. 63, 130–137.

De Biase, L.M., Nishiyama, A., and Bergles, D.E. (2010). Excitability and synaptic communication within the oligodendrocyte lineage. J. Neurosci. 30, 3600–3611.

Do, M.T.H., Kang, S.H., Xue, T., Zhong, H., Liao, H.-W., Bergles, D.E., and Yau, K.-W. (2009). Photon capture and signalling by melanopsin retinal ganglion cells. Nature 457, 281–287.

Zhu, X., Bergles, D.E., and Nishiyama, A. (2008). NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 135, 145–157.

Kang, S.H., and Bergles, D.E. (2008). Glial progenitor cells in the adult brain reveal their alternate fate. Nat. Neurosci. 11, 1365–1367.

Ziskin, J.L., Nishiyama, A., Rubio, M., Fukaya, M., and Bergles, D.E. (2007). Vesicular release of glutamate from unmyelinated axons in white matter. Nat. Neurosci. 10, 321–330.

Tritsch, N.X., and Bergles, D.E. (2007). Defining the role of astrocytes in neuromodulation. Neuron 54, 497–500.

Tritsch, N.X., Yi, E., Gale, J.E., Glowatzki, E., and Bergles, D.E. (2007). The origin of spontaneous activity in the developing auditory system. Nature 450, 50–55.

Regan, M.R., Huang, Y.H., Kim, Y.S., Dykes-Hoberg, M.I., Jin, L., Watkins, A.M., Bergles, D.E., and Rothstein, J.D. (2007). Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. J. Neurosci. 27, 6607–6619.

Ellis-Davies, G.C.R., Matsuzaki, M., Paukert, M., Kasai, H., and Bergles, D.E. (2007). 4-Carboxymethoxy-5,7-dinitroindolinyl-Glu: an improved caged glutamate for expeditious ultraviolet and two-photon photolysis in brain slices. J. Neurosci. 27, 6601–6604.

Gincel, D., Regan, M.R., Jin, L., Watkins, A.M., Bergles, D.E., and Rothstein, J.D. (2007). Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis. Exp. Neurol. 203, 205–212.

Glowatzki, E., Cheng, N., Hiel, H., Yi, E., Tanaka, K., Ellis-Davies, G.C.R., Rothstein, J.D., and Bergles, D.E. (2006). The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. J. Neurosci. 26, 7659–7664.

Paukert, M., and Bergles, D.E. (2006). Synaptic communication between neurons and NG2+ cells. Curr. Opin. Neurobiol. 16, 515–521.

Bergles, D.E. (2005). Shape-shifting at a cerebellar synapse allows submillisecond signaling. Nat. Neurosci. 8, 1279–1281.

Huang, Y.H., Sinha, S.R., Fedoryak, O.D., Ellis-Davies, G.C.R., and Bergles, D.E. (2005). Synthesis and characterization of 4-methoxy-7-nitroindolinyl-D-aspartate, a caged compound for selective activation of glutamate transporters and N-methyl-D-aspartate receptors in brain tissue. Biochemistry 44, 3316–3326.

Rothstein, J.D., Patel, S., Regan, M.R., Haenggeli, C., Huang, Y.H., Bergles, D.E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D.S., et al. (2005). Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433, 73–77.

Lin, S.-C., Huck, J.H.J., Roberts, J.D.B., Macklin, W.B., Somogyi, P., and Bergles, D.E. (2005). Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum. Neuron 46, 773–785.

Huang, Y.H., Muralidharan, S., Sinha, S.R., Kao, J.P.Y., and Bergles, D.E. (2005). Ncm-D-aspartate: a novel caged D-aspartate suitable for activation of glutamate transporters and N-methyl-D-aspartate (NMDA) receptors in brain tissue. Neuropharmacology 49, 831–842.

Lin, S., and Bergles, D.E. (2004). Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus. Nat. Neurosci. 7, 24–32.

Lin, S.-C., and Bergles, D.E. (2004). Synaptic signaling between neurons and glia. Glia 47, 290–298.

Huang, Y.H., Sinha, S.R., Tanaka, K., Rothstein, J.D., and Bergles, D.E. (2004). Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J. Neurosci. 24, 4551–4559.

Huang, Y.H., Dykes-Hoberg, M., Tanaka, K., Rothstein, J.D., and Bergles, D.E. (2004). Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. J. Neurosci. 24, 103–111.

Huang, Y.H., and Bergles, D.E. (2004). Glutamate transporters bring competition to the synapse. Curr. Opin. Neurobiol. 14, 346–352.

Lin, S.-C., and Bergles, D.E. (2002). Physiological characteristics of NG2-expressing glial cells. J. Neurocytol. 31, 537–549.

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Bergles, D.E., and Jahr, C.E. (1997). Synaptic Activation of Glutamate Transporters in Hippocampal Astrocytes. Neuron 19, 1297–1308.

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