Tag: microglia

Hidden progenitors replace microglia in the adult brain.

Microglia are highly dynamic components of the innate immune system. In this issue of Neuron, Elmore et al. (2014) report that global depletion of microglia triggers mobilization of latent microglial progenitors throughout the CNS, resulting in rapid repopulation.

Research Keywords

adult neurogenesis AMPA receptor amyotrophic lateral sclerosis (ALS) animal behavior astrocytes ATP calcium cerebellum chondroitin sulfate proteglycan cochlea development cortex demyelination electrophysiology GABA gene expression glia glioma glutamate glutamate transporter gray matter hearing onset hippocampus homeostasis inner hair cells inner supporting cells interneuron in vivo imaging mitochondria multiple sclerosis myelination neuron-glia interactions neuron-glia synapses neurovascular coupling NMDA receptors norepinephrine oligodendrocyte precursor cells oligodendrocytes oligodendrogenesis potassium purinergic signalings Purkinje cells remyelination review RNA profiling spotaneous activities

Recent news and publications

Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset
Preservation of developmental spontaneous activity enables early auditory system maturation in deaf mice
Gian inducted into Bouchet society
Dwight receives Diana Sylvestre, M.D. & Charles Homcy M.D. Professorship
Developmental spontaneous activity promotes formation of sensory domains, frequency tuning and proper gain in central auditory circuits