Tag: microglia

Hidden progenitors replace microglia in the adult brain.

Microglia are highly dynamic components of the innate immune system. In this issue of Neuron, Elmore et al. (2014) report that global depletion of microglia triggers mobilization of latent microglial progenitors throughout the CNS, resulting in rapid repopulation.

Research Keywords

adult neurogenesis AMPA receptor amyotrophic lateral sclerosis (ALS) animal behavior astrocytes ATP calcium cerebellum chondroitin sulfate proteglycan cochlea development cortex demyelination electrophysiology GABA gene expression glia glioma glutamate glutamate transporter gray matter hearing onset hippocampus homeostasis inner hair cells inner supporting cells interneuron in vivo imaging mitochondria multiple sclerosis myelination neuron-glia interactions neuron-glia synapses neurovascular coupling NMDA receptors norepinephrine oligodendrocyte precursor cells oligodendrocytes oligodendrogenesis potassium purinergic signalings Purkinje cells remyelination review RNA profiling spotaneous activities

Recent news and publications

Tonotopically distinct OFF responses arise in the mouse auditory midbrain following sideband suppression
Flexible ensheathment of axons enables myelination of complex CNS networks
Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury
Pat receives a 2026 Emerging Research Grant from the Hearing Health Foundation and Les Paul Foundation.
Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors